Dystroglycan Maintains Inner Limiting Membrane Integrity to Coordinate Retinal Development
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Mutations in Lama1 disrupt retinal vascular development and inner limiting membrane formation.
The Neuromutagenesis Facility at the Jackson Laboratory generated a mouse model of retinal vasculopathy, nmf223, which is characterized clinically by vitreal fibroplasia and vessel tortuosity. nmf223 homozygotes also have reduced electroretinogram responses, which are coupled histologically with a thinning of the inner nuclear layer. The nmf223 locus was mapped to chromosome 17, and a missense ...
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TmE micro-anatomy of the region between the retina and the vitreous has been a source of discussion and interest for more than a century. Work has, in general, been concerned with the inner surface of the retina and has involved extensive investigation of what is normally termed the inner limiting membrane. The basis for this name was very probably provided by Pacini, who referred to a homogene...
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T1TI.E SURFACE STRXXUTG (IF RABBIT VIlF'EO-Xb'l'lNAL JUNCTIDN AFTER ENZiMATTC !IEPARAT'TON OF INNER LIMITIN:: MBMBRaNE. CILVETI A. T.APEIRk VI. and GARCln CANFOS J!-l ueparcment of Ophthalmo'iocgy Urlivrrsicy of Malaga. Pu+pooc.1n order to inves?:qato the etrxct~rr :,f the inner Iuniting nembranil (TLMJ and r hC vi:reoretlnal 8trscttire. I.hn TLM was Bei>ara;ad +ron the retina irl rabbrt rlpcci...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2017
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.0946-17.2017